Coro2b^tm1.1Cya
Targeted Allele Detail

Summary

• Symbol: Coro2b^tm1.1Cya
• Name: coronin, actin binding protein, 2B; targeted mutation 1.1, Cyagen Biosciences
• MGI ID: MGI:6379356
• Synonyms: Coro2b^tm1.1Cgen
• Gene: Coro2b Location: Chr9:62326774-62444326 bp, - strand Genetic Position: Chr9, 33.71 cM
• Alliance: Coro2b^tm1.1Cya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279853
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6-8 were flanked by loxP sites. Cre-mediated recombination deleted exons 6-8 in the germline. Western blot analysis confirmed the absence of protein in kidney tissue. (J:279853)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Coro2b Mutation: 69 strains or lines available

References

• Original: J:279853 Schwarz A, et al., Coro2b, a podocyte protein downregulated in human diabetic nephropathy, is involved in the development of protamine sulphate-induced foot process effacement. Sci Rep. 2019 Jun 20;9(1):8888
• All: 1 reference(s)