Agk^tm1.1Smoc
Targeted Allele Detail

Summary

• Symbol: Agk^tm1.1Smoc
• Name: acylglycerol kinase; targeted mutation 1.1, Shanghai Model Organisms Center
• MGI ID: MGI:6381660
• Synonyms: Agk^fl, Agk-flox, Agk^tm1.1Qiz
• Gene: Agk Location: Chr6:40302106-40373696 bp, + strand Genetic Position: Chr6, 18.82 cM
• Alliance: Agk^tm1.1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282052
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 2 and an FRT site flanked antibiotic resistance gene cassette and a second loxP site into intron 3. The cassette was removed through subsequent Flp-mediated recombination, leaving a conditional-ready allele with exon 3 floxed. (J:282052)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agk Mutation: 59 strains or lines available

References

• Original: J:282052 Hu Z, et al., Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8(+) T Cells. Cell Metab. 2019 Aug 6;30(2):290-302.e5
• All: 2 reference(s)