Agk^em1Qiz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Agk^em1Qiz
• Name: acylglycerol kinase; endonuclease-mediated mutation 1, Qiang Zou
• MGI ID: MGI:6381662
• Synonyms: Agk^G126E, AGK-G126E PM
• Gene: Agk Location: Chr6:40302106-40373696 bp, + strand Genetic Position: Chr6, 18.82 cM
• Alliance: Agk^em1Qiz page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Using CRISPR/Cas9 technology, glycine codon 126 (GGC) was changed to a glutamic acid codon (GAA) (p.Gly126Glu). This creates a kinase-dead version of the peptide that is unable to phosphorylate its target lipids. (J:282052)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agk Mutation: 59 strains or lines available

References

• Original: J:282052 Hu Z, et al., Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8(+) T Cells. Cell Metab. 2019 Aug 6;30(2):290-302.e5
• All: 2 reference(s)