Tg(Pdgfrb-FLP1,Cspg4-cre/ERT2)#Bvz
Transgene Detail

Summary

• Symbol: Tg(Pdgfrb-FLP1,Cspg4-cre/ERT2)#Bvz
• Name: transgene insertion, Berislav V Zlokovic
• MGI ID: MGI:6382023
• Synonyms: Pdgfrb-Flp;Cspg4-FSF-CreER
• Transgene: Tg(Pdgfrb-FLP1,Cspg4-cre/ERT2)#Bvz Location: unknown
• Alliance: Tg(Pdgfrb-FLP1,Cspg4-cre/ERT2)#Bvz page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Pdgfrb-FLP1,Cspg4-cre/ERT2)#Bvz expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cspg4 (MGI:2153093)

• Mutation details: Two constructs consisting of one with a mouse Pdgfrb promotor driving Flp recombinase and another carring a Frt-Stop-Frt-CreERT2 cassette under the control of the mouse Cspg4 promoter were co-injected into C57BL/6 blastocysts via pronuclear injection. Five founder pups were identyfied as carrying both transgenes. One unnamed founder line was established and verified. The pound symbol (#) is used when no line name is specified and/or lines are pooled. (J:281538)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cspg4 (mouse) Summary of all recombinase alleles driven by Cspg4. Comparative matrix view of recombinase activities Alliance mouse Cspg4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:281538 Nikolakopoulou AM, et al., Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nat Neurosci. 2019 Jul;22(7):1089-1098
• All: 2 reference(s)