Slc12a3^{tm1(icre)Juha}
Targeted Allele Detail

Summary

• Symbol: Slc12a3^{tm1(icre)Juha}
• Name: solute carrier family 12, member 3; targeted mutation 1, Juliette Hadchouel
• MGI ID: MGI:6382048
• Synonyms: NCC^iCre
• Gene: Slc12a3 Location: Chr8:95055829-95092842 bp, + strand Genetic Position: Chr8, 46.46 cM
• Alliance: Slc12a3^{tm1(icre)Juha} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281403
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Slc12a3^{tm1(icre)Juha} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc12a3 (MGI:108114)

• Mutation details: A cassette containing a fusion between the cDNA of the codon improved iCre recombinase, and the sequence of the 2 viral peptide wass inserted in frame at the ATG of the Slc12a3 gene, by homologous recombination in mouse embryonic stem cells. (J:281403)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc12a3 (mouse) Summary of all recombinase alleles driven by Slc12a3. Comparative matrix view of recombinase activities Alliance mouse Slc12a3 gene page

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc12a3 Mutation: 54 strains or lines available

References

• Original: J:281403 Trepiccione F, et al., A fate-mapping approach reveals the composite origin of the connecting tubule and alerts on "single-cell"-specific KO model of the distal nephron. Am J Physiol Renal Physiol. 2016 Nov 1;311(5):F901-F906
• All: 1 reference(s)