Aldh1b1^{tm1.1(cre/ERT2)Agav}
Targeted Allele Detail

Summary

• Symbol: Aldh1b1^{tm1.1(cre/ERT2)Agav}
• Name: aldehyde dehydrogenase 1 family, member B1; targeted mutation 1.1, Anthony Gavalas
• MGI ID: MGI:6382179
• Synonyms: Aldh1b1^CreERT2, Aldh1b1^{tm2(CreERT2)Agav}
• Gene: Aldh1b1 Location: Chr4:45799022-45804604 bp, + strand Genetic Position: Chr4, 24.35 cM, cytoband B2
• Alliance: Aldh1b1^{tm1.1(cre/ERT2)Agav} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:280398
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Aldh1b1^{tm1.1(cre/ERT2)Agav} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Aldh1b1 (MGI:1919785)

• Mutation details: The targeting construct consisting of the bicistronic Aldh1b1/P2A/CreERT2 transgene followed by the FRT-PGKneo- pA-FRT selection cassette was inserted in the endogenous Aldh1b1 locus to replace the coding region of mouse Aldh1b1 gene. The neo selection cassette was removed by Flp recombinase. (J:280398)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Aldh1b1 (mouse) Summary of all recombinase alleles driven by Aldh1b1. Comparative matrix view of recombinase activities Alliance mouse Aldh1b1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aldh1b1 Mutation: 35 strains or lines available

References

• Original: J:280398 Mameishvili E, et al., Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer. Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20679-20688
• All: 1 reference(s)