Adm2^em1Zhan
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adm2^em1Zhan
• Name: adrenomedullin 2; endonuclease-mediated mutation 1, Wei Zhang
• MGI ID: MGI:6382308
• Synonyms: IMD^-
• Gene: Adm2 Location: Chr15:89206923-89208934 bp, + strand Genetic Position: Chr15, 44.81 cM
• Alliance: Adm2^em1Zhan page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9-targeting of exon 3 deleted 317 bp (encoding 92 amino acids). (J:343162)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adm2 Mutation: 11 strains or lines available

References

• Original: J:266495 Xiao F, et al., Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses. Nat Commun. 2018 Jul 6;9(1):2644
• All: 3 reference(s)