Kcnv2^{tm1.2(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Kcnv2^{tm1.2(KOMP)Wtsi}
• Name: potassium channel, subfamily V, member 2; targeted mutation 1.2, Wellcome Trust Sanger Institute
• MGI ID: MGI:6382425
• Synonyms: Kcnv2^{tm1b(KOMP)Wtsi}, Kv8.2 KO
• Gene: Kcnv2 Location: Chr19:27299988-27314579 bp, + strand Genetic Position: Chr19, 21.88 cM
• Alliance: Kcnv2^{tm1.2(KOMP)Wtsi} page
• IMPC: Kcnv2 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279816
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The L1L2_Del_BactPneo_FFL cassette was inserted at position 27396587 of Chromosome 19 upstream of exon 1 (Build 37). The cassette is composed of an FRT site followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a loxP site. A second loxP site is inserted downstream of exon 1 at position 27398917. Exon 1 is thus flanked by loxP sites. Exon 1 was deleted through subsequent cre-mediated recombination.

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnv2 Mutation: 24 strains or lines available

References

• Original: J:279816 Hart NS, et al., The Role of the Voltage-Gated Potassium Channel Proteins Kv8.2 and Kv2.1 in Vision and Retinal Disease: Insights from the Study of Mouse Gene Knock-Out Mutations. eNeuro. 2019 Jan-Feb;6(1):ENEURO.0032-19.2019
• All: 2 reference(s)