Gtf2h3em1(IMPC)J
Endonuclease-mediated Allele Detail
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Symbol: |
Gtf2h3em1(IMPC)J |
Name: |
general transcription factor IIH, polypeptide 3; endonuclease-mediated mutation 1, Jackson |
MGI ID: |
MGI:6382787 |
Gene: |
Gtf2h3 Location: Chr5:124717211-124735743 bp, + strand Genetic Position: Chr5, 63.67 cM
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Alliance: |
Gtf2h3em1(IMPC)J page
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IMPC: |
Gtf2h3 gene page |
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Strain of Origin: |
C57BL/6NJ
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Project Collection: |
IMPC
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Allele Type: |
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Endonuclease-mediated (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences CCCATGGCAAAGAAGCTGAG and ATACACCAATTCCCACCACA, which resulted in a 695 bp deletion beginning at Chromosome 5 position 124,583,657 bp and ending after 124,584,351 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001266779 and ENSMUSE00001246016 (exons 3 and 4) and 421 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 31 and early truncation 25 amino acids later.
(J:188991)
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Inheritance: |
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Not Specified |
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012; |
All: |
3 reference(s) |
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