Plgrkt^tm1Lmls
Targeted Allele Detail

Summary

• Symbol: Plgrkt^tm1Lmls
• Name: plasminogen receptor, C-terminal lysine transmembrane protein; targeted mutation 1, Lindsey Miles
• MGI ID: MGI:6384265
• Synonyms: Plgrkt^tm1Rjpr
• Gene: Plgrkt Location: Chr19:29326004-29339340 bp, - strand Genetic Position: Chr19, 23.85 cM
• Alliance: Plgrkt^tm1Lmls page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282437
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 4 through 7. Western blot analysis confirmed the absence of protein expression in thioglycollate-elicited macrophages. (J:282437)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plgrkt Mutation: 6 strains or lines available

References

• Original: J:282437 Miles LA, et al., Deficiency of plasminogen receptor, Plg-RKT , causes defects in plasminogen binding and inflammatory macrophage recruitment in vivo. J Thromb Haemost. 2017 Jan;15(1):155-162
• All: 4 reference(s)