Tg(CAG-COX7A2L)#Sinos
Transgene Detail

Summary

• Symbol: Tg(CAG-COX7A2L)#Sinos
• Name: transgene insertion, Satoshi Inoue
• MGI ID: MGI:6384937
• Synonyms: COX7RP-Tg
• Transgene: Tg(CAG-COX7A2L)#Sinos Location: unknown
• Alliance: Tg(CAG-COX7A2L)#Sinos page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-COX7A2L)#Sinos expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  COX7A2L (9167)

  Cox7a2l

  (MGI:106015)

• Mutation details: The human Flag-tagged COX7A2L is under the control of the CAG promoter. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:215964)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Cox7a2l^Gt(OST241316)Lex/Cox7a2l^Gt(OST241316)Lex Tg(CAG-COX7A2L)#Sinos/0	involves: 129S5/SvEvBrd * C57BL/6
tg2	Tg(CAG-COX7A2L)#Sinos/0	involves: C57BL/6

Phenotypes:

Affected Systems	cx1	tg2
show or hide all annotated terms
adipose tissue	√	N
adipose tissue phenotype		N
abnormal brown adipose tissue morphology	√
cellular		√
increased fibroblast proliferation		√
homeostasis/metabolism	N	√
homeostasis/metabolism phenotype	N
increased carbon dioxide production		√
increased oxygen consumption		√
increased aerobic running capacity		√
abnormal enzyme/coenzyme activity		√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:215964 Ikeda K, et al., A stabilizing factor for mitochondrial respiratory supercomplex assembly regulates energy metabolism in muscle. Nat Commun. 2013;4:2147
• All: 1 reference(s)