Tlr2^tm1(cre)Dfil
Targeted Allele Detail

Summary

• Symbol: Tlr2^tm1(cre)Dfil
• Name: toll-like receptor 2; targeted mutation 1, Dominik Filipp
• MGI ID: MGI:6385316
• Synonyms: Tlr2^Cre
• Gene: Tlr2 Location: Chr3:83743579-83749045 bp, - strand Genetic Position: Chr3, 37.4 cM
• Alliance: Tlr2^tm1(cre)Dfil page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281617
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Tlr2^tm1(cre)Dfil expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tlr2 (MGI:1346060)

• Mutation details: The targeting vector is designed to insert Cre cassettes under the control of the Tlr2 promoter by BAC recombineering. After homologous recombination in ES cells, open reading frame of Tlr2 exon 3 was substituted with Cre. (J:281617)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tlr2 (mouse) Summary of all recombinase alleles driven by Tlr2. Comparative matrix view of recombinase activities Alliance mouse Tlr2 gene page

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr2 Mutation: 60 strains or lines available

References

• Original: J:281617 Balounova J, et al., Toll-like receptor 2 expression on c-kit(+) cells tracks the emergence of embryonic definitive hematopoietic progenitors. Nat Commun. 2019 Nov 15;10(1):5176
• All: 1 reference(s)