Grin1^tm1Zwz
Targeted Allele Detail

Summary

• Symbol: Grin1^tm1Zwz
• Name: glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 1, Zhong-wei Zhang
• MGI ID: MGI:6385512
• Gene: Grin1 Location: Chr2:25181193-25209199 bp, - strand Genetic Position: Chr2, 17.14 cM
• Alliance: Grin1^tm1Zwz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was introduced to intron 4 and an frt-PGK-Neo-frt-loxP selection cassette was placed in intron 5. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:280408)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grin1 Mutation: 68 strains or lines available

References

• Original: J:280408 Liu H, et al., N-terminal alternative splicing of GluN1 regulates the maturation of excitatory synapses and seizure susceptibility. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21207-21212
• All: 2 reference(s)