Skor1^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Skor1^em1(IMPC)J
• Name: SKI family transcriptional corepressor 1; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6385903
• Gene: Skor1 Location: Chr9:63045452-63056243 bp, - strand Genetic Position: Chr9, 33.96 cM
• Alliance: Skor1^em1(IMPC)J page
• IMPC: Skor1 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences CTGTACTTCCTGCATTAAAA and AGATTATCCCAAATCCACTA, which resulted in a 345 bp deletion beginning at Chromosome 9 position 63,143,267 bp and ending after 63,143,611 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000342989 (exon 3) and 248 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 768 and early truncation 92 amino acids later. There is a 2 bp insertion (AC) at the deletion site. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Skor1 Mutation: 36 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)