Ttc1^em1(IMPC)Mbp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ttc1^em1(IMPC)Mbp
• Name: tetratricopeptide repeat domain 1; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• MGI ID: MGI:6386313
• Synonyms: Ttc1^-
• Gene: Ttc1 Location: Chr11:43620833-43638835 bp, - strand Genetic Position: Chr11, 25.81 cM, cytoband B1.1
• Alliance: Ttc1^em1(IMPC)Mbp page
• IMPC: Ttc1 gene page

Ttc1^em1(IMPC)Mbp/Ttc1^em1(IMPC)Mbp mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form irregular outgrowths with poorly defined inner cell mass colony.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele from IMPC was generated at UC Davies by injecting CAS9 Protein and 3 guide sequences CCAAAACTTAAAGCTGGCAGTGG, CTTTCGGGAAGGTAGCGTATGGG, AAACTTAAAGCTGGCAGTGGAGG, which resulted in a Exon Deletion. (J:265051)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ttc1 Mutation: 18 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 4 reference(s)