Prdm12^tm1.1Ejbd
Targeted Allele Detail

Summary

• Symbol: Prdm12^tm1.1Ejbd
• Name: PR domain containing 12; targeted mutation 1.1, Eric J Bellefroid
• MGI ID: MGI:6386418
• Synonyms: Prdm12^flox
• Gene: Prdm12 Location: Chr2:31530049-31545807 bp, + strand Genetic Position: Chr2, 21.85 cM
• Alliance: Prdm12^tm1.1Ejbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283226
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector HTGR03016_Z_6_A08 introduced upstream of exon 2 an FRT site, splice acceptor sequence, lacZ reporter gene, polyadenylation sequence, loxP site, neomycin resistance cassette, FRT site and loxP site. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the reporter and selection cassettes and left exon 2 floxed. (J:283226)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prdm12 Mutation: 26 strains or lines available

References

• Original: J:283226 Desiderio S, et al., Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA. Cell Rep. 2019 Mar 26;26(13):3522-3536.e5
• All: 4 reference(s)