Spata7^tm2.1Mrd
Targeted Allele Detail

Summary

• Symbol: Spata7^tm2.1Mrd
• Name: spermatogenesis associated 7; targeted mutation 2.1, Graeme Mardon
• MGI ID: MGI:6386673
• Synonyms: Spata7^delta1-5
• Gene: Spata7 Location: Chr12:98594416-98636074 bp, + strand Genetic Position: Chr12, 49.88 cM
• Alliance: Spata7^tm2.1Mrd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279827
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette with a 5' loxP site and two 3' FRT sites was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exons 1 through 5. (J:279827)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spata7 Mutation: 27 strains or lines available

References

• Original: J:279827 Eblimit A, et al., Conditional loss of Spata7 in photoreceptors causes progressive retinal degeneration in mice. Exp Eye Res. 2018 Jan;166:120-130
• All: 2 reference(s)