Sox9^{em1(cre/ERT2)Tchn}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sox9^{em1(cre/ERT2)Tchn}
• Name: SRY (sex determining region Y)-box 9; endonuclease-mediated mutation 1, Ting Chen
• MGI ID: MGI:6386787
• Synonyms: Sox9-Cre^ER, Sox9-CreER
• Gene: Sox9 Location: Chr11:112673050-112678586 bp, + strand Genetic Position: Chr11, 77.27 cM
• Alliance: Sox9^{em1(cre/ERT2)Tchn} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Sox9^{em1(cre/ERT2)Tchn} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sox9 (MGI:98371)

• Mutation details: A cDNA encoding IRES-cre recombinase fused with a mutant form of estrogen receptor hormone-binding domain C (ERT2) was inserted after the site encoding the translational stop codon of the Sox9 gene, using the CRISPR/Cas9 technology. (J:269510, J:278073)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sox9 (mouse) Summary of all recombinase alleles driven by Sox9. Comparative matrix view of recombinase activities Alliance mouse Sox9 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox9 Mutation: 33 strains or lines available

References

• Original: J:269510 Xu Z, et al., Embryonic attenuated Wnt/beta-catenin signaling defines niche location and long-term stem cell fate in hair follicle. Elife. 2015 Dec 14;4:e10567
• All: 17 reference(s)