Tg(Krt19-icre)2Hirt
Transgene Detail

Summary

• Symbol: Tg(Krt19-icre)2Hirt
• Name: transgene insertion 2, Hiroyuki Tomita
• MGI ID: MGI:6387216
• Synonyms: Krt19-iCre#2
• Transgene: Tg(Krt19-icre)2Hirt Location: unknown
• Alliance: Tg(Krt19-icre)2Hirt page

Transgene origin

• Strain of Origin: B6D2F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Krt19-icre)2Hirt expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Krt19 (MGI:96693)

• Mutation details: Using bacterial recombineering technology, BAC RP24-68P2 containing the entire Krt19 was used to generate a transgene with a iCre-polyA cassette replacing the ATG codon and the following 632 bps of the coding sequence in the Krt19 gene. Twelve founder lines were generated. Line 2 and 5 heterozygous showed no health issue, and the line #2 was used for the studies. (J:279102)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Krt19 (mouse) Summary of all recombinase alleles driven by Krt19. Comparative matrix view of recombinase activities Alliance mouse Krt19 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:279102 Kanayama T, et al., Characterization of a BAC transgenic mouse expressing Krt19-driven iCre recombinase in its digestive organs. PLoS One. 2019;14(8):e0220818
• All: 2 reference(s)