Tg(Camk2a-MAPT*P301L)#Atak
Transgene Detail

Summary

• Symbol: Tg(Camk2a-MAPT*P301L)#Atak
• Name: transgene insertion, Akihiko Takashima
• MGI ID: MGI:6389818
• Synonyms: P301Ltau-Tg, P301L-Tg
• Transgene: Tg(Camk2a-MAPT*P301L)#Atak Location: unknown
• Alliance: Tg(Camk2a-MAPT*P301L)#Atak page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-MAPT*P301L)#Atak expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: The human 4 repeat tau containing the P301L mutation and myc and FLAG tags at the N- and C-terminals, respectively, is under the control of the Camk2 promoter. The pound symbol (#) is used when line is not specified and/or lines are pooled. Mice show a 3-5-fold overexpression of the mutant tau relative to endogenous mouse tau. (J:167329)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:167329 Kimura T, et al., Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss. J Biol Chem. 2010 Dec 3;285(49):38692-9
• All: 5 reference(s)