Gpr63^em1Rstot
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gpr63^em1Rstot
• Name: G protein-coupled receptor 63; endonuclease-mediated mutation 1, Rolf W Stottmann
• MGI ID: MGI:6391252
• Synonyms: Gpr63^Arg(B6)
• Gene: Gpr63 Location: Chr4:24966407-25009233 bp, + strand Genetic Position: Chr4, 10.53 cM, cytoband A3
• Alliance: Gpr63^em1Rstot page

Mutation origin

• Strain of Origin: FVB

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: Using CRISPR/Cas9 technology, a T>G mutation was created in the FVB strain, converting a deleterious mutation (SNP rs13477613) in FVB (and A/J) to the reference, non-pathogenic, sequence of the B6 strain. This results in a serine codon in FVB changing to the B6 arginine codon. (J:282171)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr63 Mutation: 27 strains or lines available

References

• Original: J:282171 Snedeker J, et al., Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants. PLoS Genet. 2019 Nov;15(11):e1008467
• All: 1 reference(s)