Cd2bp2^tm1.2Tbh
Targeted Allele Detail

Summary

• Symbol: Cd2bp2^tm1.2Tbh
• Name: CD2 cytoplasmic tail binding protein 2; targeted mutation 1.2, Tobias Huber
• MGI ID: MGI:6392027
• Gene: Cd2bp2 Location: Chr7:126790832-126795222 bp, - strand Genetic Position: Chr7, 69.38 cM
• Alliance: Cd2bp2^tm1.2Tbh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283435
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 1. An additional loxP site was inserted downsteam of exon 3. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 1 through 3 floxed. Western blot analysis confirmed the absence of protein expression in embryos. (J:283435)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd2bp2 Mutation: 26 strains or lines available

References

• Original: J:283435 Albert GI, et al., The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function. J Mol Cell Biol. 2015 Oct;7(5):402-14
• All: 1 reference(s)