Dntt^em2(icre)Trx
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dntt^em2(icre)Trx
• Name: deoxynucleotidyltransferase, terminal; endonuclease-mediated mutation 2, Roxane Tussiwand
• MGI ID: MGI:6392142
• Synonyms: TdT^iCre
• Gene: Dntt Location: Chr19:41017714-41047964 bp, + strand Genetic Position: Chr19, 34.32 cM
• Alliance: Dntt^em2(icre)Trx page

Mutation origin

• Strain of Origin: C57BL/6JRj

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Dntt^em2(icre)Trx expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Dntt (MGI:98659)

• The stop codon has been replaced by the self cleaving peptide E2A followed by icre. (J:325398)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Dntt (mouse) Summary of all recombinase alleles driven by Dntt. Comparative matrix view of recombinase activities Alliance mouse Dntt gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dntt Mutation: 34 strains or lines available

References

• Original: J:325398 Klein F, et al., Dntt expression reveals developmental hierarchy and lineage specification of hematopoietic progenitors. Nat Immunol. 2022 Apr;23(4):505-517
• All: 1 reference(s)