Iqsec2^em1Csbg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Iqsec2^em1Csbg
• Name: IQ motif and Sec7 domain 2; endonuclease-mediated mutation 1, Cheryl Shoubridge
• MGI ID: MGI:6392156
• Gene: Iqsec2 Location: ChrX:150927193-151008232 bp, + strand Genetic Position: ChrX, 68.46 cM
• Alliance: Iqsec2^em1Csbg page

Mutation origin

• Strain of Origin: C57BL/6NHsd

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting removed exon 3 in both main isoforms. Exons 2, 4, and 5 are not affected. (J:284750)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Iqsec2 Mutation: 12 strains or lines available

References

• Original: J:284750 Jackson MR, et al., Heterozygous loss of function of IQSEC2/Iqsec2 leads to increased activated Arf6 and severe neurocognitive seizure phenotype in females. Life Sci Alliance. 2019 Aug;2(4)
• All: 2 reference(s)