Dux^em1Ditr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dux^em1Ditr
• Name: double homeobox; endonuclease-mediated mutation 1, Didier Trono
• MGI ID: MGI:6392158
• Synonyms: Dux^-
• Gene: Dux Location: unknown Genetic Position: Chr10, Syntenic

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR genome editing technology was used to generate a deletion of the Dux macrosatellite repeat region. Absence of RNA expression was confirmed in the testis of adult homozygous male mice. (J:284179)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dux Mutation: 1 strain or line available

References

• Original: J:284179 De Iaco A, et al., DUX is a non-essential synchronizer of zygotic genome activation. Development. 2020 Jan 23;147(2):dev177725
• All: 1 reference(s)