Tulp3^m1Kflj
Chemically induced Allele Detail

Summary

• Symbol: Tulp3^m1Kflj
• Name: TUB like protein 3; mutation 1, Karel F Liem Jr
• MGI ID: MGI:6392262
• Synonyms: Tulp3^K407I
• Gene: Tulp3 Location: Chr6:128298124-128332814 bp, - strand Genetic Position: Chr6, 62.96 cM
• Alliance: Tulp3^m1Kflj page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: This mutation, identified in an ENU mutagenesis screen, is an adenine to thymine transversion in exon 10 at position 1220 resulting in a lysine to isoleucine substitution at position 407. This mutation is within the tubby domain. (J:284006)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tulp3 Mutation: 54 strains or lines available

References

• Original: J:284006 Legue E, et al., Tulp3 Is a Ciliary Trafficking Gene that Regulates Polycystic Kidney Disease. Curr Biol. 2019 Mar 4;29(5):803-812.e5
• All: 2 reference(s)