Arel1^em1Bbc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Arel1^em1Bbc
• Name: apoptosis resistant E3 ubiquitin protein ligase 1; endonuclease-mediated mutation 1, Bill B Chen
• MGI ID: MGI:6392853
• Synonyms: Kiaa0317^-
• Gene: Arel1 Location: Chr12:84964922-85017674 bp, - strand Genetic Position: Chr12, 39.46 cM
• Alliance: Arel1^em1Bbc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 13 was targeted using an sgRNA and CRISPR/Cas9 technology, resulting in a 91 bp deletion spanning the 3' end of exon 13 and the 5' end of intron 13. The transcripts expressed from this allele skip the 3'-incomplete exon 13 (resulting in a frameshift and premature termination) and total transcription levels are reduced. (J:280563)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arel1 Mutation: 34 strains or lines available

References

• Original: J:280563 Lear TB, et al., KIAA0317 regulates pulmonary inflammation through SOCS2 degradation. JCI Insight. 2019 Oct 3;4(19)
• All: 1 reference(s)