Gars1^em2Rwb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gars1^em2Rwb
• Name: glycyl-tRNA synthetase 1; endonuclease-mediated mutation 2, Robert W Burgess
• MGI ID: MGI:6393282
• Synonyms: Gars^deltaETAQ
• Gene: Gars1 Location: Chr6:55014992-55056485 bp, + strand Genetic Position: Chr6, 27.29 cM
• Alliance: Gars1^em2Rwb page

Mutation origin

• Strain of Origin: (FVB/NJ x C57BL/6NJ)F1

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a 12 bp deletion (bases 12-23) in exon 8. (J:284948)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gars1 Mutation: 42 strains or lines available

References

• Original: J:284948 Morelli KH, et al., Allele-specific RNA interference prevents neuropathy in Charcot-Marie-Tooth disease type 2D mouse models. J Clin Invest. 2019 Dec 2;129(12):5568-5583
• All: 3 reference(s)