Col1a1^{tm1(tetO/CMV-Lep)Rll}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm1(tetO/CMV-Lep)Rll}
• Name: collagen, type I, alpha 1; targeted mutation 1, Rudolph L Leibel
• MGI ID: MGI:6393313
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm1(tetO/CMV-Lep)Rll} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283599
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: RCME on KH2 cells inserted a cassette that contains the tetracycline response element and CAG promoter driving inducible expression of the mouse Leptin gene followed by the hygromycin B selection gene. (J:283599)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 163 strains or lines available

Notes

This allele was generated with Col1a1^{tm13(neo/hygro*)Jae}.

References

• Original: J:283599 Skowronski AA, et al., Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice. Sci Transl Med. 2020 Jan 1;12(524)
• All: 2 reference(s)