Foxa2^tm1.1Khk
Targeted Allele Detail

Summary

• Symbol: Foxa2^tm1.1Khk
• Name: forkhead box A2; targeted mutation 1.1, Kalus H Kaestner
• MGI ID: MGI:6393315
• Gene: Foxa2 Location: Chr2:147884797-147888889 bp, - strand Genetic Position: Chr2, 73.38 cM
• Alliance: Foxa2^tm1.1Khk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:284174
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A single loxP site was inserted into intron 2 and a loxP flanked neomycin and thymidine kinase selection cassette was inserted into intron 3. The selection cassette was removed in ES cells by transient Cre expression prior to the production of chimeric mice, leaving exon 2 flanked by loxP sites in the final allele. Cre-mediated recombination deleted exon 2 in the germline. (J:63039, J:284174)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxa2 Mutation: 28 strains or lines available

References

• Original: J:63039 Sund NJ, et al., Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol Cell Biol. 2000 Jul;20(14):5175-83
• All: 2 reference(s)