Rnu11^tm1.1Rank
Targeted Allele Detail

Summary

• Symbol: Rnu11^tm1.1Rank
• Name: U11 small nuclear RNA; targeted mutation 1.1, Rahul N Kanadia
• MGI ID: MGI:6393645
• Synonyms: Rnu11^Flx
• Gene: Rnu11 Location: Chr4:131997390-131997497 bp, - strand Genetic Position: Chr4, 65.08 cM
• Alliance: Rnu11^tm1.1Rank page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266583
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the gene, and an FRT site flanked neomycin resistance gene cassette and a second loxP site downstream. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with the gene floxed. (J:266583)

Expression

In Mice Carrying this Mutation:	175 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnu11 Mutation: 1 strain or line available

References

• Original: J:266583 Baumgartner M, et al., Minor spliceosome inactivation causes microcephaly, owing to cell cycle defects and death of self-amplifying radial glial cells. Development. 2018 Aug 28;145(17):dev166322
• All: 4 reference(s)