Dexi^em1Kslr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dexi^em1Kslr
• Name: dexamethasone-induced transcript; endonuclease-mediated mutation 1, Stephan Kissler
• MGI ID: MGI:6393839
• Synonyms: Dexi^allele#1
• Gene: Dexi Location: Chr16:10348071-10360918 bp, - strand Genetic Position: Chr16, 5.67 cM
• Alliance: Dexi^em1Kslr page

Mutation origin

• Strain of Origin: NOD/ShiLtJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 1 resulting in a near complete deletion. Western blot analysis confirmed the absence of protein expression. (J:285312)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dexi Mutation: 9 strains or lines available

References

• Original: J:285312 Nieves-Bonilla JM, et al., The type 1 diabetes candidate gene Dexi does not affect disease risk in the nonobese diabetic mouse model. Genes Immun. 2020 Jan;21(1):71-77
• All: 1 reference(s)