Tmprss9tm1.3Hzo
Targeted Allele Detail
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Symbol: |
Tmprss9tm1.3Hzo |
Name: |
transmembrane protease, serine 9; targeted mutation 1.3, Huda Y Zoghbi |
MGI ID: |
MGI:6393876 |
Synonyms: |
Tmprss9-, Tmprss9tm1.3Arte |
Gene: |
Tmprss9 Location: Chr10:80707682-80735326 bp, + strand Genetic Position: Chr10, 39.72 cM
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Alliance: |
Tmprss9tm1.3Hzo page
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Germline Transmission: |
Earliest citation of germline transmission:
J:284914
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6NTac
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A gene trap cassette containing an FRT site, attB site, Puromycin resistance gene, attP site, human growth hormone poly(A) signal sequence, and FRT site was inserted between exon 1 and exon 2. In addition, exon 2 was flanked by loxP sites. The Puromycin resistance gene was removed via PhiC31-mediated recombination. The human growth hormone poly(A) signal sequence was removed via Flp-mediated recombination. Cre-mediated recombination deleted exon 2. Deletion of exon 2 leads to a frameshift and premature stop codon in exon 3.
(J:284914)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tmprss9 Mutation: |
40 strains or lines available
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Original: |
J:284914 Chen CA, et al., Combination of whole exome sequencing and animal modeling identifies TMPRSS9 as a candidate gene for autism spectrum disorder. Hum Mol Genet. 2020 Feb 1;29(3):459-470 |
All: |
1 reference(s) |
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