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Tmprss9tm1.3Hzo
Targeted Allele Detail
Summary
Symbol: Tmprss9tm1.3Hzo
Name: transmembrane protease, serine 9; targeted mutation 1.3, Huda Y Zoghbi
MGI ID: MGI:6393876
Synonyms: Tmprss9-, Tmprss9tm1.3Arte
Gene: Tmprss9  Location: Chr10:80707682-80735326 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance: Tmprss9tm1.3Hzo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:284914
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA gene trap cassette containing an FRT site, attB site, Puromycin resistance gene, attP site, human growth hormone poly(A) signal sequence, and FRT site was inserted between exon 1 and exon 2. In addition, exon 2 was flanked by loxP sites. The Puromycin resistance gene was removed via PhiC31-mediated recombination. The human growth hormone poly(A) signal sequence was removed via Flp-mediated recombination. Cre-mediated recombination deleted exon 2. Deletion of exon 2 leads to a frameshift and premature stop codon in exon 3. (J:284914)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tmprss9 Mutation:  40 strains or lines available
References
Original:  J:284914 Chen CA, et al., Combination of whole exome sequencing and animal modeling identifies TMPRSS9 as a candidate gene for autism spectrum disorder. Hum Mol Genet. 2020 Feb 1;29(3):459-470
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory