Ehd2^tm1.1Cbm
Targeted Allele Detail

Summary

• Symbol: Ehd2^tm1.1Cbm
• Name: EH-domain containing 2; targeted mutation 1.1, Carmen Birchmeier
• MGI ID: MGI:6394087
• Synonyms: Ehd2^del
• Gene: Ehd2 Location: Chr7:15680883-15701402 bp, - strand Genetic Position: Chr7, 8.65 cM
• Alliance: Ehd2^tm1.1Cbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:285350
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. A neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 and the selection cassette. (J:285350)

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ehd2 Mutation: 27 strains or lines available

References

• Original: J:285350 Matthaus C, et al., EHD2-mediated restriction of caveolar dynamics regulates cellular lipid uptake. bioRxiv. 2020
• All: 5 reference(s)