Cdnf^tm1Uhb
Targeted Allele Detail

Summary

• Symbol: Cdnf^tm1Uhb
• Name: cerebral dopamine neurotrophic factor; targeted mutation 1, University of Helsinki, Biocenter
• MGI ID: MGI:6394117
• Synonyms: Cdnf^Pu
• Gene: Cdnf Location: Chr2:3514102-3527413 bp, + strand Genetic Position: Chr2, 1.99 cM
• Alliance: Cdnf^tm1Uhb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:285339
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• A floxed puromycin resistance cassette with a 3' loxP site replaced exons 2 through 4. (J:285339)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdnf Mutation: 13 strains or lines available

References

• Original: J:285339 Lindahl M, et al., Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice. Neurobiol Dis. 2020 Feb;134:104696
• All: 1 reference(s)