Dnase1^tm2092.1Arte
Targeted Allele Detail

Summary

• Symbol: Dnase1^tm2092.1Arte
• Name: deoxyribonuclease I; targeted mutation 2092.1, TaconicArtemis
• MGI ID: MGI:6400348
• Gene: Dnase1 Location: Chr16:3855007-3857888 bp, + strand Genetic Position: Chr16, 2.37 cM, cytoband A1-A3
• Alliance: Dnase1^tm2092.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277126
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 to 8 were replaced with a Puromycin selection cassette flanked by F3 sites. Flp-mediated recombination removed the selection cassette. RT-PCR confirmed the absence of the Dnase1 transcript but presence of the overlapping Trap1 transcript. (J:277126)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnase1 Mutation: 28 strains or lines available

References

• Original: J:277126 Kenny EF, et al., Dnase1-deficient mice spontaneously develop a systemic lupus erythematosus-like disease. Eur J Immunol. 2019 Apr;49(4):590-599
• All: 1 reference(s)