Rbm45^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rbm45^em1(IMPC)J
• Name: RNA binding motif protein 45; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6400536
• Gene: Rbm45 Location: Chr2:76200328-76214112 bp, + strand Genetic Position: Chr2, 44.94 cM
• Alliance: Rbm45^em1(IMPC)J page
• IMPC: Rbm45 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences AGAATATACAGACATGCAAA and ACTTGCTTACAACTACCAAC, which resulted in a 763 bp deletion beginning at Chromosome 2 position 76,378,345 bp and ending after 76,379,107 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000358265, ENSMUSE00000388560, and ENSMUSE00000345417 (exons 6, 7, and 8) and 294 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 286 and early truncation 5 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rbm45 Mutation: 31 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)