Ighg1^em1Wliu
Chemically induced Allele Detail

Summary

• Symbol: Ighg1^em1Wliu
• Name: immunoglobulin heavy constant gamma 1 (G1m marker); endonuclease-mediated mutation 1, Wanli Liu
• MGI ID: MGI:6400764
• Synonyms: G390R, IGHG1^T
• Gene: Ighg1 Location: Chr12:113290161-113294143 bp, - strand Genetic Position: Chr12, 62.1 cM
• Alliance: Ighg1^em1Wliu page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU) (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology using two sgRNAs 5'-CATGATTGGGCAAGCACCCT-3' and 5'-GTGGGGTATAGGTCACCAC-3' generated a glycine to arginine substitution at amino acid 390 (G390R). The mouse G390R mutation is equivalent to the human G396R variant commonly found in East Asian populations and is correlated with susceptibility to systemic lupus erythematosus. (J:266937)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ighg1 Mutation: 28 strains or lines available

References

• Original: J:266937 Chen X, et al., An autoimmune disease variant of IgG1 modulates B cell activation and differentiation. Science. 2018 Nov 9;362(6415):700-705
• All: 2 reference(s)