Mef2b^tm2Rdf
Targeted Allele Detail

Summary

• Symbol: Mef2b^tm2Rdf
• Name: myocyte enhancer factor 2B; targeted mutation 2, Riccardo Dalla-Favera
• MGI ID: MGI:6400973
• Synonyms: Mef2b^stopD83V
• Gene: Mef2b Location: Chr8:70605411-70620138 bp, + strand Genetic Position: Chr8, 34.15 cM, cytoband C1
• Alliance: Mef2b^tm2Rdf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265465
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Null/knockout)
• Mutations: Insertion, Single point mutation
• Mutation details: A loxP site flanked neomycin resistance gene and STOP cassette pair was inserted into intron 2. Exon 3 was replaced with a version containing a mutation that changes aspartic acid codon 83 into a valine codon (p.D83V). This creates a conditional-ready null allele that expresses the full mutated transcript only after cre-mediated removal of the neo and STOP cassettes. (J:265465)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mef2b Mutation: 22 strains or lines available

References

• Original: J:265465 Brescia P, et al., MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis. Cancer Cell. 2018 Sep 10;34(3):453-465.e9
• All: 1 reference(s)