Peli2^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Peli2^tm1.1Arte
• Name: pellino 2; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:6401217
• Synonyms: Peli2^-
• Gene: Peli2 Location: Chr14:48358280-48519032 bp, + strand Genetic Position: Chr14, 24.6 cM
• Alliance: Peli2^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265431
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT site flanked puromycin resistance gene cassette replaced exons 2-6 (representing the majority of coding region and the entire 3' UTR). The puro cassette was removed through subsequent flp-mediated recombination. PCR experiments confirmed lack of expression from this null allele in bone marrow-derived macrophages (BMDMs). (J:265431)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Peli2 Mutation: 25 strains or lines available

References

• Original: J:265431 Humphries F, et al., The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome. Nat Commun. 2018 Apr 19;9(1):1560
• All: 1 reference(s)