Rhoatm1.1Tpal
Targeted Allele Detail
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Symbol: |
Rhoatm1.1Tpal |
Name: |
ras homolog family member A; targeted mutation 1.1, Teresa Palomero |
MGI ID: |
MGI:6401218 |
Synonyms: |
Rhoaco-G17V |
Gene: |
Rhoa Location: Chr9:108183359-108215142 bp, + strand Genetic Position: Chr9, 59.2 cM
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Alliance: |
Rhoatm1.1Tpal page
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Germline Transmission: |
Earliest citation of germline transmission:
J:257764
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready) |
Mutations: |
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Insertion, Single point mutation
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Mutation details: Exon 3 was replaced with a minigene containing Rhoa exons 3 to 6 flanked by loxP sites followed by a neomycin selection cassette and a mutant exon 3 encoding a glycine to valine substitution at amino acid 17. The selection cassette was removed via Flp-mediated recombination. In the absence of cre recombinase, exon 2 is spliced into exons 3-6 minigene resulting in expression of a wild-type mRNA. In the presence of cre recombinase, the floxed exon 3-6 minigene is removed and the mutant G17V allele is expressed.
(J:257764)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rhoa Mutation: |
73 strains or lines available
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Original: |
J:257764 Cortes JR, et al., RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis. Cancer Cell. 2018 Feb 12;33(2):259-273.e7 |
All: |
3 reference(s) |
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