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Rhoatm1.1Tpal
Targeted Allele Detail
Summary
Symbol: Rhoatm1.1Tpal
Name: ras homolog family member A; targeted mutation 1.1, Teresa Palomero
MGI ID: MGI:6401218
Synonyms: Rhoaco-G17V
Gene: Rhoa  Location: Chr9:108183359-108215142 bp, + strand  Genetic Position: Chr9, 59.2 cM
Alliance: Rhoatm1.1Tpal page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:257764
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutations:    Insertion, Single point mutation
 
Mutation detailsExon 3 was replaced with a minigene containing Rhoa exons 3 to 6 flanked by loxP sites followed by a neomycin selection cassette and a mutant exon 3 encoding a glycine to valine substitution at amino acid 17. The selection cassette was removed via Flp-mediated recombination. In the absence of cre recombinase, exon 2 is spliced into exons 3-6 minigene resulting in expression of a wild-type mRNA. In the presence of cre recombinase, the floxed exon 3-6 minigene is removed and the mutant G17V allele is expressed. (J:257764)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rhoa Mutation:  73 strains or lines available
References
Original:  J:257764 Cortes JR, et al., RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis. Cancer Cell. 2018 Feb 12;33(2):259-273.e7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory