Aida^tm1.1Scli
Targeted Allele Detail

Summary

• Symbol: Aida^tm1.1Scli
• Name: axin interactor, dorsalization associated; targeted mutation 1.1, Sheng-Cai Lin
• MGI ID: MGI:6401842
• Synonyms: Aida^-
• Gene: Aida Location: Chr1:183078604-183105356 bp, + strand Genetic Position: Chr1, Syntenic
• Alliance: Aida^tm1.1Scli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262001
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron and an FRT site flanked neomycin resistanc gene cassette and a second loxP site into intron 2. The neo cassette and exon 2 were deleted through subsequent cre-mediated recombination. (J:262001)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aida Mutation: 15 strains or lines available

References

• Original: J:262001 Luo H, et al., AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity. Cell Metab. 2018 Apr 3;27(4):843-853.e6
• All: 1 reference(s)