Tg(SFTPC-DPP4)3Pbmj
Transgene Detail

Summary

• Symbol: Tg(SFTPC-DPP4)3Pbmj
• Name: transgene insertion 3, Paul B McCray Jr
• MGI ID: MGI:6402180
• Synonyms: SPC-hDPP4
• Transgene: Tg(SFTPC-DPP4)3Pbmj Location: unknown
• Alliance: Tg(SFTPC-DPP4)3Pbmj page

Transgene origin

• Strain of Origin: C57BL/6J x SJL/J

Transgene description

• Transgene Type: Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SFTPC-DPP4)3Pbmj expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DPP4 (1803)

  Dpp4	(MGI:94919)

• Mutation details: A FLAG epitope-tagged human DPP4 cDNA is under the control of the human surfactant protein C promoter. The promoter directs expression of the Middle East respiratory coronavirus receptor in bronchiolar and alveolar epithelia. Eight lines were generated. (J:285467)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:285467 Li K, et al., Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4. J Infect Dis. 2016 Mar 1;213(5):712-22
• All: 1 reference(s)