Tg(CAG-DPP4)4Yuzh
Transgene Detail

Summary

• Symbol: Tg(CAG-DPP4)4Yuzh
• Name: transgene insertion 4, Yusen Zhou
• MGI ID: MGI:6402443
• Transgene: Tg(CAG-DPP4)4Yuzh Location: unknown
• Alliance: Tg(CAG-DPP4)4Yuzh page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-DPP4)4Yuzh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DPP4 (1803)

  Dpp4	(MGI:94919)

• Mutation details: A codon-optimized human DPP4 is under the control of the CAG promoter. Four lines (1-4) were generated. Line 4 shows high lung viral titer after infection with Middle East respiratory coronavirus. (J:286175)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:286175 Zhao G, et al., Multi-Organ Damage in Human Dipeptidyl Peptidase 4 Transgenic Mice Infected with Middle East Respiratory Syndrome-Coronavirus. PLoS One. 2015;10(12):e0145561
• All: 4 reference(s)