Procr^tm2.1Yaz
Targeted Allele Detail

Summary

• Symbol: Procr^tm2.1Yaz
• Name: protein C receptor, endothelial; targeted mutation 2.1, Yi Arial Zeng
• MGI ID: MGI:6402575
• Synonyms: Procr^mGFP-2A-LacZ
• Gene: Procr Location: Chr2:155593037-155597391 bp, + strand Genetic Position: Chr2, 77.26 cM, cytoband H1-3
• Alliance: Procr^tm2.1Yaz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286193
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector containing a membrane bound GFP (mGFP), a viral 2A oligopeptide (that mediates ribosomal skipping), and a lacZ reporter followed by an FRT-flanked neomycin resistance cassette was inserted after the ATG start site of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:286193)

Expression

In Mice Carrying this Mutation:

37 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Procr Mutation: 15 strains or lines available

Notes

ES cell line = B6 1-6

References

• Original: J:286193 Wang D, et al., Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr(+) Progenitors. Cell. 2020 Mar 19;180(6):1198-1211.e19
• All: 2 reference(s)