Arhgef7^tm1Dprk
Targeted Allele Detail

Summary

• Symbol: Arhgef7^tm1Dprk
• Name: Rho guanine nucleotide exchange factor; targeted mutation 1, Dongeun Park
• MGI ID: MGI:6402582
• Synonyms: betaPix-KO
• Gene: Arhgef7 Location: Chr8:11778053-11885219 bp, + strand Genetic Position: Chr8, 5.73 cM
• Alliance: Arhgef7^tm1Dprk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:284300
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A floxed neomycin resistance cassette replaced exon 19. (J:284300)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgef7 Mutation: 54 strains or lines available

References

• Original: J:284300 Kang T, et al., Loss of Pix Causes Defects in Early Embryonic Development, and Cell Spreading and PlateletDerived Growth Factor-Induced Chemotaxis in Mouse Embryonic Fibroblasts. Mol Cells. 2019 Aug 31;42(8):589-596
• All: 3 reference(s)