Tg(CAG-ACE2)AC63Ctkt
Transgene Detail

Summary

• Symbol: Tg(CAG-ACE2)AC63Ctkt
• Name: transgene insertion AC63, Chien-Te K Tseng
• MGI ID: MGI:6402829
• Synonyms: AC63
• Transgene: Tg(CAG-ACE2)AC63Ctkt Location: unknown
• Alliance: Tg(CAG-ACE2)AC63Ctkt page

Transgene origin

• Strain of Origin: (C57BL/6J x C3H/HeJ)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-ACE2)AC63Ctkt expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ACE2 (59272)

  Ace2	(MGI:1917258)

• Mutation details: The human ACE2 cDNA is under the control of the CAG promoter (consisting of the cytomegalovirus immediate-early enhancer and the chicken beta-actin promoter). Five lines (AC12, AC22, AC50, AC63, and AC70) were generated with two, AC70 and AC63 further analyzed. Transgene expression is lower in the AC63 line than in the AC70 line. (J:117824)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1	Tg(CAG-ACE2)AC63Ctkt/0	either: (involves: BALB/c * C3H/HeJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6 * C57BL/6J)

Phenotypes:

Affected Systems	tg1
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immune system	√
increased susceptibility to Coronaviridae infection	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:117824 Tseng CT, et al., Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor. J Virol. 2007 Feb;81(3):1162-73
• All: 4 reference(s)