Brf1^tm1Arte
Targeted Allele Detail

Summary

• Symbol: Brf1^tm1Arte
• Name: BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit; targeted mutation 1, TaconicArtemis
• MGI ID: MGI:6403351
• Synonyms: Brf1^fl
• Gene: Brf1 Location: Chr12:112923705-112964324 bp, - strand Genetic Position: Chr12, 61.47 cM, cytoband F2
• Alliance: Brf1^tm1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:285667
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 3 was floxed. An FRT-flanked neomycin cassette was inserted upstream of exon 3. (J:285667)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brf1 Mutation: 23 strains or lines available

References

• Original: J:285667 Liko D, et al., Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas. Cell Death Differ. 2019 Dec;26(12):2535-2550
• All: 1 reference(s)