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Rnf43em2Mage
Endonuclease-mediated Allele Detail
Summary
Symbol: Rnf43em2Mage
Name: ring finger protein 43; endonuclease-mediated mutation 2, Markus Gerhard
MGI ID: MGI:6403354
Synonyms: Rnf43H292R/H295R
Gene: Rnf43  Location: Chr11:87553913-87626365 bp, + strand  Genetic Position: Chr11, 52.17 cM
Alliance: Rnf43em2Mage page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Nucleotide substitutions
 
Mutation detailsHistidine codons 292 and 295 were targeted for mutation to arginine codons with an oligonucleotide donor sequence and an sgRNA using CRISPR/Cas9. This resulted in p.His292Arg and p.His295Arg mutations (plus a silent mutation) in this allele. The mutations in the RING domain lead to transactivation of Wnt signalling. (J:276360)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rnf43 Mutation:  36 strains or lines available
References
Original:  J:276360 Neumeyer V, et al., Loss of endogenous RNF43 function enhances proliferation and tumour growth of intestinal and gastric cells. Carcinogenesis. 2019 Jun 10;40(4):551-559
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory