Hprt1^{tm1(CAG-BRF1)Gu}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(CAG-BRF1)Gu}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, University of Glasgow
• MGI ID: MGI:6403376
• Synonyms: HPRT^LSL-BRF1
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(CAG-BRF1)Gu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:285667
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:285667 Liko D, et al., Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas. Cell Death Differ. 2019 Dec;26(12):2535-2550
• All: 1 reference(s)